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周怀瑜 简介

周怀瑜,男,医学博士学位,博士研究生学历,山东大学副教授,硕士研究生导师,国家自然科学基金同行评议专家,国家精品课程寄生虫学网站主持人,山东大学形态学实验中心副主任,中华预防医学会寄生虫学分会会员,中国微生物学终身会员,印度Agricultural Research Communication Centre会员,国际SCI期刊《Journal of Proteomics》、《Vaccine》、《Parasitology Research》、《African Journal of Microbiology Research》、《Experimental Parasitology》、《Journal of Chromatography B》、《Journal of Basic Microbiology》、《BioScience Trends》、《Indian Journal of Animal Research》、《Journal of Integrative Agriculture》、《Journal of Integrative Agriculture》、《Trials in Vaccinology》、《Brazilian Journal of Microbiology》、《Microbiology - Concepts and Applications》等审稿专家。
        1992年至今先后担任临床医学、预防医学、卫生检验、高等护理、成人教育等专业的研究生、本科生、留学生、专科生等层次的寄生虫学教学。主编教材3部,参编专著6部,其中英文专著1部。主持国家自然科学基金面上项目1项,主持山东省科学技术发展计划项目1项,主持山东省优秀中青年科学家科研奖励基金项目1项,主持山东省医药卫生科技发展项目1项;为主参加国家级科研课题2项和省部级科研课题4项。掌握细胞培养、基因克隆与表达、蛋白质纯化与鉴定、Genotyping、PCR、RT-PCR、Western Blot、ELISA、蛋白质组学和生物信息学等技术与方法。在国内外核心期刊发表论文50余篇,其中SCI论文20余篇。2009年12月-2011年1月留学于美国田纳西大学(The University of Tennessee)微生物系。2013年分别被评为山东省和山东大学优秀研究生学位论文指导教师。

研究方向与兴趣:
1
、弓形虫分子生物学和免疫学
2
、蛋白质疫苗和DNA疫苗及其免疫策略
3
、寄生虫蛋白质组学与生物信息学

论文论著:
1. Zhou H * #(周怀瑜,第一作者兼通讯作者), Min J #, Zhao Q, Gu Q, Cong H, Li Y, He S. Protective immune response against Toxoplasma gondii elicited by a recombinant DNA vaccine with a novel genetic adjuvant. Vaccine. 2012 Feb 27;30 (10): 1800-6 .(SCI影响因子3.766)
2. Zhou H * #(周怀瑜,第一作者兼通讯作者), Zhao Q, Singla LD, Min J, He S, Cong H, Li Y, Su C #. Differential proteomic profiles from distinct Toxoplasma gondii strains revealed by 2D-difference gel electrophoresis. Exp Parasitol. 2013 Apr; 133(4): 376-82.(SCI影响因子2.122)
3. Zhou H #(周怀瑜,第一作者), Gu Q, Zhao Q, Zhang J, Cong H, Li Y, He S. Toxoplasma gondii: expression and characterization of a recombinant protein containing SAG1 and GRA2 in Pichia pastoris. Parasitol Res. 2007 Mar; 100(4): 829-35. (SCI影响因子2.149)
4. Min J, Qu D, Li C, Song X, Zhao Q, Li XA, Yang Y, Liu Q, He S, Zhou H *(周怀瑜,通讯作者). Enhancement of protective immune responses induced by Toxoplasma gondii dense granule antigen 7 (GRA7) against toxoplasmosis in mice using a prime-boost vaccination strategy. Vaccine. 2012 Aug 17; 30(38): 5631-6. (SCI影响因子3.766)
5. Liu Q, Singla LD, Zhou H *(周怀瑜,通讯作者). Vaccines against Toxoplasma gondii: Status, challenges and future directions. Hum Vaccin Immunother. 2012 Sep; 8(9): 1305-8. (SCI影响因子3.577)
6. Liu Q, Wang F, Wang G, Zhao Q, Min J, Wang S, Cong H, Li Y, He S, Zhou H *(周怀瑜,通讯作者). Toxoplasma gondii: Immune response and protective efficacy induced by ROP16 / GRA7 multicomponent DNA vaccine with a genetic adjuvant B7-2. Hum Vaccin Immunother. 2014; 10(1): 2860-2867. (SCI影响因子3.577)
7. Qu D #, Zhou H #(周怀瑜,共同第一作者), Han J, Tao S, Zheng B, Chi N, Su C, Du A. Development of reverse transcription loop-mediated isothermal amplification (RT-LAMP) as a diagnostic tool of Toxoplasma gondii in pork. Vet Parasitol. 2013 Feb 18; 192(1-3): 98-103. (SCI影响因子2.579)
8. Bai Y, He S, Zhao G, Chen L, Shi N, Zhou H周怀瑜), Cong H, Zhao Q, Zhu XQ. Toxoplasma gondii: bioinformatics analysis, cloning and expression of a novel protein TgIMP1. Exp Parasitol. 2012 Dec; 132(4): 458-64. (SCI影响因子2.122)
9. Meng M, He S, Zhao G, Bai Y, Zhou H周怀瑜), Cong H, Lu G, Zhao Q, Zhu XQ. Evaluation of protective immune responses induced by DNA vaccines encoding Toxoplasma gondii surface antigen 1 (SAG1) and 14-3-3 protein in BALB/c mice. Parasit Vectors. 2012 Nov 26;5:273. (SCI影响因子2.937)
10. Dubey JP, Velmurugan GV, Rajendran C, Yabsley MJ, Thomas NJ, Beckmen KB, Sinnett D, Ruid D, Hart J, Fair PA, McFee WE, Shearn-Bochsler V, Kwok OC, Ferreira LR, Choudhary S, Faria EB, Zhou H周怀瑜), Felix TA, Su C. Genetic characterisation of Toxoplasma gondii in wildlife from North America revealed widespread and high prevalence of the fourth clonal type. Int J Parasitol. 2011 Sep;41(11):1139-47. (SCI影响因子3.393)
11. Cong H, Gu QM, Yin HE, Wang JW, Zhao QL, Zhou HY(周怀瑜), Li Y, Zhang JQ. Multi-epitope DNA vaccine linked to the A2/B subunit of cholera toxin protect mice against Toxoplasma gondii. Vaccine. 2008 Jul 23;26(31):3913-21. (SCI影响因子3.766)
12. Zhang J, He S, Jiang H, Yang T, Cong H, Zhou H(周怀瑜), Zhang J, Gu Q, Li Y, Zhao Q. Evaluation of the immune response induced by multiantigenic DNA vaccine encoding SAG1 and ROP2 of Toxoplasma gondii and the adjuvant properties of murine interleukin-12 plasmid in BALB/c mice. Parasitol Res. 2007 Jul;101(2):331-8. (SCI影响因子2.149)
13. Zhang J, Gu Q, Hou X, Zhou H(周怀瑜), Cong H, Li Y, Zhao Q, Li S. Identification of a necessary element for Toxoplasma gondii SAG1 gene expression. Exp Parasitol. 2007 Jun;116(2):175-81. (SCI影响因子2.122)
14. Dubey JP, Rajendran C, Ferreira LR, Martins J, Kwok OC, Hill DE, Villena I, Zhou H(周怀瑜), Su C, Jones JL. High prevalence and genotypes of Toxoplasma gondii isolated from goats, from a retail meat store, destined for human consumption in the USA. Int J Parasitol. 2011 Jul;41(8):827-33. (SCI影响因子3.393)
15. Cong H, Gu QM, Jiang Y, He SY, Zhou HY(周怀瑜), Yang TT, Li Y, Zhao QL. Oral immunization with a live recombinant attenuated Salmonella typhimurium protects mice against Toxoplasma gondii. Parasite Immunol. 2005 Jan-Feb;27(1-2):29-35. (SCI影响因子2.601)
16. Zhao G H, Zhou A H ,Lu G, Meng M, Sun M, Bai Y, Han Y L, Wang L, Zhou HY(周怀瑜), Cong H, Zhao Q L, Zhu X Q, He S Y*. Identification and characterization of Toxoplasma gondii aspartic protease 1 as a novel vaccine candidate against toxoplasmosis. Parasite Vectors 6(175), 2013. (SCI影响因子2.937)
17. Zhao G H, Zhou A H*, Lu G, Meng M, Sun M, Bai Y, Han Y L, Wang L, Zhou H Y(周怀瑜), Cong H, Zhao Q L, Zhu X Q , He S Y*. Toxoplasma gondii cathepsin proteases are undeveloped prominent vaccine antigens against toxoplasmosis. BMC INFECT DIS, 13(207), 2013. (SCI影响因子3.118)
18. Meng M, Zhou A H, Lu G, Wang L, Zhao G H, Han Y L, Zhou H Y(周怀瑜), Cong H, Zhao Q L,Zhu X Q, He S Y*. DNA prime and peptide boost immunization protocol encoding the Toxoplasma gondii GRA4 induces strong protective immunity in BALB/c mice. BMC INFECT DIS, 13(494), 2013 . (SCI影响因子3.118)
19、周怀瑜主编《微生物学学习指导》,2010年,山东大学出版社。
20、周怀瑜主编《人体寄生虫学应试指南》,2005年,同济大学出版社。
21、周怀瑜参编《医学节肢动物学》,2009年,人民卫生出版社。
22、周怀瑜参编《寄生虫学实验研究技术》,2008年,人民卫生出版社。
23、周怀瑜参编《医学昆虫学》,2007年,人民军医出版社。
24、周怀瑜插图《人体寄生虫学》八年制全国统编教材,2005年,人民卫生出版社。
25、周怀瑜参编《医学寄生虫学》全国“十二五”规划教材,2013年,北京大学医学出版社。
26、周怀瑜参编《Zoonoses: Parastic and Mycotic Diseases》,2013年,DAYA PUBLISHING HOUSE, NEW DELHI, INDIA.


联系方式:
通讯地址:济南市文化西路4476信箱,邮编250012
办公电话:0531-88382042
E-mail: zhouhuaiyu@yeah.net

 

1 参加弓形虫与弓形虫病国际学术会议(中国黄山)

 

2 留学于美国田纳西大学(University of Tennessee

     

 

3 参加美国第20届分子寄生虫学年会(University of Georgia

 

4 与美国科学院院士Dr. Dubey在一起(NIMBioS at Knoxville,TN)

     

 

Berkely College

 

Brown University

     

 

 

 

Vanderbilt university

 

 Harvard University

     

 

 

 

 Florida State University

 

 Washington University in St. Louis

     

 

 

 

 The University of Utah

 

 University of Alabama at Birmingham

     

 

 

 

 University of Maine

 

 Universty of Cincinnati

     

 

 

 

 Massachusetts Institute of Technology 

 

Rhode Island College

     

 

 

 

Yale University

 

Virginia Commonwealth University

 

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